By using the bookVibe History of Hip Hop, Yes, Yes Yall, and unit 1&4, Essay

By using the bookVibe History of Hip Hop, Yes, Yes Yall, and unit 1, critique and comparing and contrasting the information, the presentation, the relevance - Essay Example Such as his song for Hailie in 'mocking bird' and how he feels he has screwed up for her in 'when I'm gone'. Rap is music, music is entertainment, rap is feelings and emotions and to entertain with feelings and emotions one has to be able to gain control of them to be able to logic whether a person is proper or improper in the means they show their mentality. Not all rappers do this whether because they feel it's a freedom and democracy of discussion and rapping about what could drive others crazy or about the dictatorship of what they believe to be correct and true on life issues which they have learned growing up, like 50-cent's saying that where he comes from has no plan B so he's got to take the chances he's got to be able to face life consequently 'properly'. Most youth have no experience in life except what they read, listen to in music and thus relate to it in a manner which is shallow because it is shallow in words and this is why they could 'relate' because it is not literature by Victor Hugo or Roman Roland in his tragedy 'Antoinette'.

Obama's Health Care Reform 2010 Research Paper Example | Topics and Well Written Essays - 3500 words

Obama's Health Care Reform 2010 - Research Paper Example Proposals to reform The US’ Health Care Legislation have severally failed until March 23, 2010 when President Obama and his Democratic party leaders were able to pass and sign the bill. This paper delves into the Obamas Health Care Reform 2010, the most expansive social legislation ratified in decades, and explains how will lead to a significant change/overhaul to the United States’ current health care system. On 23 March 2010; after one roller-coaster year of heated partisan combat, negotiations and hearings looking into health care details, and an almost-death political encounter after Obama together with other Congress Democratic leaders seemed to have reached the brink of success; President Obama signed the Health Care Reform legislation. Through a 220 – 215vote, the House had approved its bill during the month of November (7th) in the year 2009, while on December 24, the the Senate passed an 871 billion dollars bill. In a dramatic vote, the House endorsed the landmark health care bill 219 to 212 the house had to overhaul the United States’ health care system and warrant that millions of Americans get access to medical insurance. This is following decades of numerous Democratic presidents’ futile attempts, including Bill Clinton and Harry Truman, thereby making the moment very essential in the long legislative combat.   After two days, the Senate and the House c oncluded the passage of a set of fixes to the bills, concessions developed as a component of the intricate legislative manipulation that permitted the attainment of Democrats’ long-sought goal in spite of having missed out on their obstructionist-proof sixty-vote ‘supermajority’ two months earlier in the Senate in January. This bill is expected to offer coverage to approximately thirty million Americans who at present do not have access to it. The bill necessitates Americans to ensure that they have health insurance coverage and would subsidize private coverage for middle

Process Essay Sample Will Give You a Clue How to Make Your Work an Excellent One

Process Essay Sample Will Give You a Clue How to Make Your Work an Excellent One Process Essay Sample Will Give You a Clue How to Make Your Work an Excellent One Try to Use Our Tips in Writing Your Academic Essay Process essays are academic essay type that should clarify the sequence of actions that should be done to complete definite task. Such kind of essay involves the absolute understanding in the subject to be talked about. You would never effectively explain the issues that you are not acquainted with. Essay needs a skill, especially when you want to make a procedure or process essay writing. So, when you need to advance your work, process essay sample may well be brought into play. Actually, preparing an essay can be an engaging duty. It lets you try to express your point of view and attitude to the problem. Moreover, it may let a writer demonstrate his writing talent, or express his position. 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Thats why it would be desirable to look though a number of samples of reference to learn and ensure how quotations are written. We always have different types of custom essay and they all are of high quality. Besides you can check them out at your own leisure. If you are still not certain enough, then you can buy essay or order a work on any of diverse research paper topics we offer. Choosing Suitable and Successful Sociology Paper Topics -Find Out How to Select Right Topic for Your Paper on Sociology Sociology is defined by some people as the learning of persons social behavior, particularly the study of the beginning, culture, society, and growth of human society or it can also be identified as an investigation of a societal part as a self-contained body. So, sociology is a gigantic and a very exciting subject and choosing right sociology paper topics is a very important moment in your academic life. 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It is usually agreed that the current particular interest in the sociology of the human has developed owing to some major causes: Up-to-dateness and a human. The society and a human. It shows what sociology is about as a subject. There are some attractive sociology papers themes on sociology: The Theory of Culture. The Theory of Exchange. The Theory of Feminists. The Theory of a Conflict. The Basics of Marxism. The Structural Functionalism. The Interactions of the Symbols. The Theory of a System. The Methodology of Ethnology. It is some of the theories that are made use of in sociology. They are usually applied for diverse aims in the issue. Some of them can be easily done in the shape of discussion essay as these hypotheses are unfamiliar to many people. You can make a variety of appealing sociology paper themes from these points. 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The aim of your work is to explain and talk about complex relations among technology and society. You should make clear how some exacting technology problems have an influence on people. You can illustrate freely the impact on any area of recent time that your technology has influenced mainly. As no other research paper technology essay needs accuracy, clarity and uniformity in presenting the thoughts. For your theme you must choose the technology that truly interests you. However you dont have to select something too novel or complex. Gather some related data (using as a minimum 4 resources). Keep in mind, that you always can make use of internet and libraries. At this moment in time you may perhaps wish to curtail your theme, if you have collected too much relevant information. And on the contrary if you have too little appropriate facts on the elected area of study, make your theme more universal. The major necessity to the informational sources is their trustworthiness. Take in your work only newest facts that contain true data up to this day. Dont trust in out-of-date writing. Essay involves not only making the text, but helpful and considerate reading too. As you are looking through the resources you have composed, take out the most significant information for your work. And finally there comes writing as it is. Make the first sketch of your work, taking into account the subsequent information: The foreword should comprise a well-built theory, which you will expand in the course of your work. Present some proof for each statement that you formulate. Submit an application of specific technology language properly. By no means fail to quote the resources you applied in your work. The ending repeats the main points of your work. It should enclose a influential phrase, reflecting the key thought of the whole work. Your first sketch requires review and editing. You can offer your work to someone else who is familiar in the theme of your work. Their commentary will aid you to formulate your work in more rational, balanced and grammatically right way. Bearing in mind these simple advice youll surely be competent enough to compose a nice technology essay on any given topic. Still, if you want to be sure in the excellent result of your work you can simply buy essay here choosing any types of essays on a number of interesting research ideas. The Master Essay Writing Can Be an Enjoyable Experience Read Our Tips of Preparing a Master Essay and Get Ready to Accomplish This Task Very Well Making for a Master level is a specific doings. It is non-natural in that sense that it is modified to a very particular aim, like lawful drafting or even poems. Its only other environment is in the sheets of educational journals. The majority of the grand works of writing, history, beliefs, and most authorized reports would not probably exceed in Master essay writing. The Master Essay usually takes about 5-10 pages. This work will not be topic to an oral protection or an examination, but will be read by any associate of the Department as well as by the essay controller. Its arrangement should keep to the guidelines given by your study institution. Usually towards the end of the Winter Term the learner should present a proposal for his Master Essay. This application must be no more than 2 pages in length, representing the theme or dilemma to be coped with and the approach to resolve it. An example bibliography is to be given as well. The application should have the agreement of your essay controller till it is approved to the graduate planner. Some extra reader will be determined together by the controller and graduate planner. With the intention of giving the needed time to the Master Essay learners are sturdily advised not to bring unfinished assignments from the Autumn or Winter Terms of study. The Master Essay should be an investigation work shoeing proper proficiency in the submission of hypothetical and practical approaches. The Master Essay can be developed from one of the earlier essay from one of the learners classes. It can be made on the basis of main study, or it can be an interpretive work based on less important resources. Anyway, high-quality analysis and text are wanted. The learner, controller, graduate planner, and additional person who will read your essay will enlarge a plan for the completion of such work, choosing a time for its final defense. With the aim of completing the essay within a year, as it is required, the 8th of August is the final date to do the work, once studied and accepted by the controller, in the hands of the extra person who reads. This person will state about the work within 14 days of getting it. This information will succeed, not pass, or advise slight alterations to the essay. 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Personal Narrative - Severe Chest Pain Attack :: essays research papers

Silent Killer Today was like supposed to be just like every other day. On another early Monday morning, just like every time I had to get up 2 hours before school, I woke up and went downstairs for breakfast at 6:30. I clean the mess from last night’s dinner with my brother and get ready to go with my carpool to school, because just like every other day, gas is expensive. Funny thing about the carpool, which comes at 7:00 sharp, 7:30 came and she didn’t show up, Therefore, we ended up waking up my father and dragging his tired angry self to school. I had forgotten my wallet at home, so I wasn’t going to have lunch and I didn’t eat breakfast either. Around 11:00, I start my pre-calculus class where we are doing long division of polynomial functions when it hits me. Pain. Intense sharp needle like pain in my chest. Subtle at first, but as I continue breathing, the pain gets worse. So, to solve this, I thought my chair was too tight to the desk. I moved back. Not helping. Clenched at the chest and bent over. Breathed slower. Not helping. Tore off my jacket and bent over in my chair fully. Not helping. And my breath kept getting shorter and shorter until I was barely gasping one every 5 seconds. I reached over and hit my friend and she got the point. Mr. Courtney phoned the principal, vice principal and school administrator. They all came down and told me to lie on the floor. By this time, I was nauseous and convulsing because of lack of oxygen and trauma. I lie there shaking as my teacher moves tables and finds jackets so that I can get my head elevated. The students leave the classroom. My teeth start chattering and I am near tears when the paramedics come in, 8 grown men with machines, clipboards, walkie talkies, and suits storm into the classroom and strap things on me. A red-lighted finger clamp to check my pulse, a blood pressure thing on my arm to check my blood, and 4 sticky clamps attached to wired to check other vitals of some sort. After 15 minutes, the pain subsides almost completely, except when I started to stand. Vital signs, good. Blood pressure, Good. Pulse, strong steady and fast. Adrenaline rush, maybe. Anxiety attack, maybe. Hospitalization, not necessary. By that time, they had called my mom and she came down from North Scottsdale in 14 minutes.

Presence of Illuminati Through Ideologies Essay

Final Draft: Presence of Illuminati through Ideologies The term â€Å"Illuminati† has been frequently used by historians in the past millennium to name secretive groups that existed and operated during the past few centuries. One of the more important secretive groups and the most famous Illuminati group until date were known as the Bavarian Illuminati although today it is simply known as â€Å"The Illuminati†. According to a source, it was founded in 1776 by a group of intellectual, European-based scientists, also known as freethinkers, during the Enlightenment era as a result of demoralization by religious factions of their belief that scientific ideologies could exist side-by-side with different religious teachings (â€Å"Illuminati†, n. d. ). Of the religious factions that somewhat stood against science, the Vatican City’s Catholic Church is thought to have continuously oppressed advances in the scientific field by these European-based scientists and hence contributed largely in the formation of an Illuminati fraternity whose members solely believed in scientific logic. Barkun (2003) believes the Illuminati existed for a small period in time, roughly eleven years, before being brought down due to infiltration among themselves by the Bavarian government in the year 1787. Yet, because of the secrecy and infiltration among regional governments the Illuminati were known for, many people believed and still believe in their rather peak period after their supposed downfall. Illuminati ideologies like science over religion and total world control on upper hierarchy by single entity unknowingly being part of our systems can result in too much authority to the group that no longer includes only scientists but also highly powerful people. According to Stone (2004), present day influential bankers, industrialists(-1-) nd statesman situated in the Western Europe and North American regions follow Illuminati ideologies that affect most of the other countries in the world excluding very few Islamic countries and China who have been able to only just resist the influence. Many theories have come up stating that the Illuminati was able to gradually infiltrate the higher levels of Free Masons, another secrecy group, whose lower hierarchy was and is popular with the pu blic, perhaps to gain some sort of insulation. In fact, it can be noticed in western-based education systems in the world today where science and scientific logic is more often than not given more importance than different religious perspectives. Opponents of this point argue that religion in general is understood and practiced by a very large number people side-by side with scientific studies and logic. These people deem scientific logic as still very young in comparison to religious logic and that science has ever since been changing not only in terms of developing new things but also in terms of modifying old findings while religion does not seem to go against itself. Although it is true that religion is practiced by a very large number of people, the fact that it is not promoted enough in educational institutes influenced by western-based education (-2-) systems in comparison to science today shows how the ideology of science over religion has slowly sneaked into the education sector itself. It can be seen that in places where science and western-based education systems are flourishing, a lot of people tend to look at everything based on the scientific logic and are gradually deviating from religious teachings that are mostly only inherited from parents today without them really knowing about it. Stone (2004) had once said in one of his articles that through control of institutes of higher studies, the western primary, secondary and tertiary education systems will be influenced by the authority of science. According to another writer known as Bradshaw, David Tappan, a professor of Divinity at Harvard, had once warned the college’s students of the extent of influence Illuminati agents had in the newly created United States of America (2003). Tappan had also talked about how one of the main aims of these influential people was to gain total control over the direction of education in the States. We can see in our small history how education of any type or in any field has played a very important role in the world when it comes to developing peoples’ minds and somewhat molding their way of thinking. Add to this the main idea of the article â€Å"Rising above the Storm: Science Education in the 21st Century,† that increase in science education is the key for the future of the U. S. economy and that the National Science Teachers Association (NSTA) should work to increase promotion of science in western-based education systems (n. d. ) and we can see how influence of science over religion is greater than ever through these education systems that are already science-based increasing the likeliness of Illuminati presence. Another Illuminatist ideology is that of infiltration among governments. Opponents of this ideology believe that the representatives of the Illuminati are merely highly publicized for(-3-) nfiltration among many North American and Western Europe governments and gain of power to affect world decisions perhaps due to the Illuminati’s background of successful infiltrations among many governments in the past. They use the point that we live in a world of many strong democratic nations with some nations still continuing to be under sovereign rule today to argue that it is highly unlikely that the Illuminatists are able to infiltrate governmen ts today. They also argue that even if they somehow manage to do so, they will not be able to influence any final decision-making due to the fact that so many government policies and rules are in place in each country to facilitate decision-making and that it seems far-fetched to think that such strong governments not only have been infiltrated by a few people but also have lost too much authority or power in making important decisions among each of the nations. With so many nations becoming democratic, we can see how easy it has become for Illuminatists to infiltrate other governments through the spread of democratic policies and get closer to achieving enough power to affect the entire world’s decisions making the likely or eventual existence of the Illuminati a possibility indeed. Examples of a few events that were against the beliefs of many democratic nations but yet took place are the forceful formation of the Jewish nation of Israel and the creation of region-based trading blocs’ side-by-side with promotion of free trade. Creation of a region-based trading bloc binds its regional country members into some sort of a single empire or one country and affects in the sense that it causes sudden changes to the way people in individual countries used to work and trade with other regional and non-regional countries. A third Illuminatist ideology is that of collecting real or natural wealth through the private banking sector. Banking is not something new but the ways banks function has always been changing in the course of our history. Private interest-rate banking was also another centuries old development but became increasingly popular among the general public from the late 18th century as a mode of safely storing and easily trading accumulated natural wealth such as gold and rare metals through paper receipts commonly known to us today as money or(-5-) currency. These receipts, initially basically used to replace unnecessary physical transactions of gold and metals, are now looked upon as a symbol of wealth. Since this operational system of storing real wealth and giving out receipts allows for easy movement and calculation of wealth which in turn results in quicker bank-related transactions, private banking is thought to have played a huge role role in economic development of many nations. From the average individual bank user to the big businesses and bankers themselves comprises a large group of ardent supporters of private banking and they undoubtedly argue in favor of private interest-rate banking. Their point of argument is based on the basic idea that private banking is the competitive and essential sector of banking where private firms compete against each other with the main aim of making huge profits and so it is very difficult if not impossible for followers of Illuminati ideology of natural wealth collection to use private interest-rate banking to their advantage and affect world economies. There is no doubt that wealth transfer has been made easy through banking but this has happened at the replacement of natural reserves of gold, oil and land with paper and electronic money/currency for economic transactions. All Illuminati ideologies lead to the main aim of gradual formation of a single entity, more commonly known as â€Å"New World Order† (NWO), by controlling positions in the upper hierarchy of each country’s ruling body through the spread of organizations in support of democratic policies, the removal of sovereignty and the creation of international organizations such as United Nations and hence affecting the individual people negatively.

Cellphones Should Not Be Allowed in School Essay

Although may not everybody would agree I believe cellphones should not be allowed in schools. First of all, cellphones can be a distraction to students. Secondly, students can use the cellphones to cheat on a test, quiz, or classwork. Lastly, it can be stolen. To start off, cellphones should not be allowed in school because they can interrupt the class and teacher. For example, if a professor is teaching a class a new lesson and suddenly a cellphones starts to ring, the teacher will have to stop the class and talk to the pupil. After that, they would have to remember their â€Å"train of thought†. Additionally, cellphones can interrupt the class when an exam or quiz is in session. In a recent article done by the New York Times, it was stated that 75% of an eighth grade class failed their state exam because of a cellphone interruption. In other words, the cellphone was â€Å"yelling† really loud, the students were not concentrating and it was difficult to turn off. Furthermore, cellular phones should be allowed in school because it can be a cheating tool. For instance, if a scholar took an exam before their friend and their buddy did not study, that person taking the test can take a picture of the questions to show to their companion. Usually, the student(s) are not caught but when they get caught the superintendent, who runs all the public, charter, private or boarding schools in a city, hears about it and the school can have a terrible reputation. Also, when a minor cheats on a huge test (state test, mid-terms, final-terms, etc.) they can especially get in trouble. Equally important, cellphones should not be allowed in schools because it can be stolen. Read more:  Should Cellphones Be Banned in Schools Essay Many youngsters bring their high-tech cellphones to school, to show it off. However, when their cellphone gets stolen, the child and their parents are furious and that means money coming out of pockets to buy a new phone. Statistics have shown that 80% of the time, the lost or stolen cellphone is not found. Therefore, I consider parents keep their children’s cellphone at home and cellphones should not be allowed in schools. My opponents may say that, cellphones can be used for emergencies. I disagree! During emergencies, the school have telephones available for staff and students and if the minor can’t use the telephones they can ask an adult to call for them. Moreover, my adversaries might say that cellphones can be used as tools when needed. In my opinion, this statement is wrong because school is a place of learning. As a result, it has all the materials youngsters need to learn like, calculators, notepads, and maps, so that scholars can use the resources they have at school and not from the piece of technology in their pocket. In summation, cellular phones should not be allowed in school because it can be a distraction, a cheating resource and it can be stolen or lost. When in school, children should pay attention to their education than the daily gossip spread on the internet.

The Gift of the Magi Quotes

'The Gift of the Magi' Quotes The Gift of the Magi by O. Henry is a holiday favorite. The cherished moments in this work have become a Christmas tradition both in the original and many iterations. Do you remember the quotes? Perhaps youve read or heard the lines without even realizing it. Here are a few quotes from the short story and here are some questions to think about. Quotes Which instigates the moral reflection that life is made up of sobs, sniffles, and smiles, with sniffles predominating.Suddenly she whirled from the window and stood before the glass. her eyes were shining brilliantly, but her face had lost its color within twenty seconds.She got out her curling irons and lighted the gas and went to work repairing the ravages made by generosity added to love. Which is always a tremendous task, dear friendsa mammoth task.His eyes were fixed upon Della, and there was an expression in them that she could not read, and it terrified her. It was not anger, nor surprise, nor disapproval, nor horror, nor any of the sentiments that she had been prepared for. He simply stared at her fixedly with that peculiar expression on his face.A mathematician or a wit would give you the wrong answer. The magi brought valuable gifts, but that was not among them. This dark assertion will be illuminated later on.And here I have lamely related to you the uneventful chronicle o f two foolish children in a flat who most unwisely sacrificed for each other the greatest treasures of their house. But in a last word to the wise of these days let it be said that of all who give gifts these two were the wisest. O all who give and receive gifts, such as they are wisest. Everywhere they are wisest. They are the magi.

How credible is smiths hypothesis concerning monastic inves essays

How credible is smiths hypothesis concerning monastic inves essays How credible is smiths hypothesis concerning monastic investment in agriculture? Use case studies to support your answer. Smiths hypothesis seems to be that in the circumstances of the 13th century being an age of rising production in which a feudal reaction occurred, the Benedictines invested productively in agriculture and were pioneers of agriculture. However, Smith never describes or presents his ideas as a hypothesis and therefore leaves some doubt regarding what his hypothesis is. For this reason it may be more sensible to analyse and assess the credibility of smiths ideas concerning investment in agriculture. A second caveat is that Smiths ideas are not principally about monastic investment but rather about the relationship between Benedictine monasteries, agriculture and the economy. The credibility of Smiths ideas therefore depends largely on whether or not medieval agrarian life and economy is as he suggests. In his study of Canterbury Priory Smith cites a number of features and characteristics of the monastery and the economy which supports his basic argument. The fact that the Priory was greatly in debt when Henry of Eastry took up the priorate but managed to clear all its debts by the end of his tenure supports this idea in two ways. Debt would have acted as an incentive to use resources productively and the fact that the debt was cleared suggests that money was coming in. Perhaps the key point in this period in support of Smiths idea is the rising price of corn, something which the priory had access to in abundance. It is clear that this rise in prices coincided with the transition back to demesne farming, giving the abbeys far greater control over production and use of agriculture. These set of circumstance suggest that not only might the monasteries like to make a profit from agriculture but were also ideally placed to do so. ...

Religion and the Syrian Civil War

Religion and the Syrian Civil War Religion played a minor but important role in the conflict in Syria. A United Nations report released in late 2012 said that the conflict was becoming â€Å"overtly sectarian† in some parts of the country, with Syria’s various religious communities finding themselves on the opposite sides of the fight between the government of President Bashar al-Assad and Syria’s fractured opposition. Growing Religious Divide At its core, the civil war in Syria is not a religious conflict. The dividing line is one’s loyalty to Assad’s government. However, some religious communities tend to be more supportive of the regime than others, fueling mutual suspicion and religious intolerance in many parts of the country. Syria is an Arab country with a Kurdish and Armenian minority. In term of religious identity, most of the Arab majority belong to the Sunni branch of Islam, with several Muslim minority groups associated with Shiite Islam. Christians from different denominations represent a smaller percentage of the population. The emergence among anti-government rebels of hard-line Sunni Islamist militias fighting for an Islamic state has alienated the minorities. Outside interference from  Shiite Iran, Islamic State militants who seek to include  Syria as part of their widespread caliphate and Sunni Saudi Arabia  makes matters worse, feeding into the wider Sunni-Shiite tension in the Middle East. Alawites   President Assad belongs to the Alawite minority, an offshoot of Shiite Islam that is specific to Syria (with small population pockets in Lebanon). The Assad family has been in power since 1970 (Bashar al-Assads father, Hafez al-Assad, served as president from 1971 until his death in 2000), and although it presided over a secular regime, many Syrians think Alawites have enjoyed privileged access to top government jobs and business opportunities. After the outbreak of the anti-government uprising in 2011, the vast majority of Alawites rallied behind the Assad regime, fearful of discrimination if the Sunni majority came to power. Most of the top rank in Assads army and intelligence services are Alawites, making the Alawite community as a whole closely identified with the government camp in the civil war. However, a group of religious Alawite leaders claimed independence from Assad recently, begging the question of whether the Alawite community is itself splintering in its support of Assad. Sunni Muslim Arabs A majority of Syrians are Sunni Arabs, but they are politically divided. True, most of the fighters in rebel opposition groups under the  Free Syrian Army  umbrella come from the Sunni provincial heartlands, and many Sunni Islamists don’t consider Alawites to be real Muslims. The armed confrontation between largely Sunni rebels and the Alawite-led government troops at one point led some observers to see Syria’s civil war as a conflict between Sunnis and Alawites. But, it’s not that simple. Most of the regular government soldiers fighting the rebels are Sunni recruits (though thousands have defected to various opposition groups), and Sunnis hold leading positions in the government, the bureaucracy, the ruling Baath Party and the business community. Some businessmen and middle-class Sunnis support the regime because they want to protect their material interests. Many others are simply scared by Islamist groups within the rebel movements and don’t trust the opposition. In any case, the bedrock of support from sections of the Sunni community has been key to Assad’s survival. Christians The Arab Christian minority in Syria at one time enjoyed relative security under Assad, integrated by the regime’s secular nationalist ideology. Many Christians fear that this politically repressive but religiously tolerant dictatorship will be replaced by a Sunni Islamist regime that will discriminate against minorities, pointing to the prosecution of Iraqi Christians by Islamist extremists after the fall of Saddam Hussein. This led to the Christian establishment: the merchants, top bureaucrats, and religious leaders, to support the government or at least distance themselves from what they saw as a Sunni uprising in 2011. And although there are many Christians in the ranks of the political opposition, such as the Syrian National Coalition, and among the pro-democracy youth activists, some rebel groups now consider all Christians to be collaborators with the regime. Christian leaders, meanwhile, are now faced with the moral obligation to speak out against Assads extreme violence and atrocities against all Syrian citizens regardless of their faith. The Druze Ismailis The Druze and the Ismailis are two distinct Muslim minorities believed to have developed out of the Shiite branch of Islam. Not unlike other minorities, The Druze and Ismailis fear that the regime’s potential downfall will give way to chaos and religious persecution. The reluctance of their leaders to join the opposition has often been interpreted as tacit support for Assad, but that isnt the case. These minorities are caught between extremist groups like the Islamic State, Assads military and opposition forces in what one Middle East analyst, Karim Bitar, from the think tank IRIS calls the tragic dilemma of religious minorities. Twelver Shiites While most Shiites in Iraq, Iran, and Lebanon belong to the mainstream Twelver branch, this principal form of Shiite Islam is only a tiny minority in Syria, concentrated in parts of the capital city of Damascus. However, their numbers swelled after 2003 with the arrival of hundreds of thousands of Iraqi refugees during the Sunni-Shiite civil war in that country. Twelver Shiites fear a radical Islamist takeover of Syria and largely support the Assad regime. With Syria’s ongoing descent into conflict, some Shiites moved back to Iraq. Others organized militias to defend their neighborhoods from Sunni rebels, adding yet another layer to the fragmentation of Syria’s religious society.

Nisbette and Wilsons Article Example | Topics and Well Written Essays - 750 words

Nisbette and Wilsons - Article Example In order to classify the result and manifestations of mental processes, Nisbette and Wilson categorized the subjects into different forms. In the awareness in the existence of the response, mental processes depend on other external contributions of the environment. A person could not act based on this theory without the acceptance or judgment of other people. In this case, a person will become knowledgeable or responsive into a certain action with the verification or response coming from the extrinsic force. In the awareness of the existence of a change process, there is a process of change in the mental awareness of a person. Subject of change varied depending on the opinions of other people as part of the environment of a certain person. Because of this, existence of the person's response will depend on the rationality of the opinion of others rather than his or her own. When it comes to cognitive process, mental processes will depend on the cognition of knowledge and learning. ... (239) In the subliminal perception, logical interpretation and existence is the focus. In this theory, it is said, "we cannot perceived without perceiving, but we can perceive without remembering." This theoretical statement shows that logic thinking is the primary base of subliminal perception. Because subliminal means subconscious, the subconscious mind will process the cognition of subjects. Therefore, perceiving can be done through the subconscious without the process of recalling. However, those observations, and researches contained different erroneous reports that lead to undetermined justifications as basis of those researchers. Erroneous reports came from the topics of stimuli influencing associative behavior, position effects on appraisal and choice, anchoring effects on predictions, the influence of an individual's personality on reactions to his physical characteristics, and emotional impact to the literary passage. Other than these are the effects of distractions on reactions to the film and the effects of reassurance on willingness to take electric shocks. Erroneous reports on these mental processes can be a disturbance to the needs of the research foundation of mental processes but still, it can be a form of outlet to define the concept of truth and reality. When it comes to the accuracy and inaccuracy of verbal explanations, Nisbette and Wilson gave different perceptions towards the report of verbal acquisition and occurrence towards their subjects. They have obtained different strategies and researches in order to avoid erroneous reports. It should be noted that the individual's private access to content would sometimes allow him to

Forensics Report #1 Coursework Example | Topics and Well Written Essays - 1250 words

Forensics Report #1 - Coursework Example This computer was Dean’s workstation. It had been taken to the IT service center within the same week. It was missing, but only because it have been taken to IT service center. It would be brought back to the station on the following Friday. Mr. Dean used the USB Drive to store his work related files as the Assistant Chief Security Officer. After its analysis, it was found that nothing that could incriminate Mr. Dean since the files in the USB drive reflected his urge to work in parallel with the company’s interest. After carrying out substantial research and reviewing all the evidence present, it is imperative to note that there was some inconsistency regarding the manner in which the particular employee resigned. The fact that the laptop case was found below the table adds to the suspicions because if the person resigned honorably, he would have at least left the laptop case on top of the table. The factors stated are some of those that led to the forensic examiners becoming involved with the case. The USB disc found ought to receive special examination to determine the information stored in it. The fact that the Chief Executive asked that the workstation computer be transferred back to the work office is an imperative step to take for it saw to it that information was not deleted from the computer at which the particular employee was working. The manner in which the employee terminated his employee is somehow suspicious and this is because for an organization such as the one given in the study, it is a requirement to tender a formal resignation by writing a letter and submitting to the relevant authorities in the organization. Going through the evidence may bring out information tying the particular worker to some illegal activities (Kiely, 2011). Either that or the employee was blackmailed out of his work. The room should also be wiped for fingerprints and this might assist in identifying the

Making a Golf Ball More Aerodynamic Essay Example | Topics and Well Written Essays - 1500 words

Making a Golf Ball More Aerodynamic - Essay Example From the research it can be comprehended that it is highly anticipated that the results will answer the age-old question of how far a dimpled ball can go. There has been many studies completed with respect to improving the yardage of balls through the use of engineered golf clubs and improved golf greens; but, not much testing has been conducted in improving the ball’s internal mechanisms. The purpose of this study is to not only understand the inner workings of the golf ball and a breakdown of the materials used in the balls of today, but, also to further understand the aerodynamics of how the ball travels in the air and water. Through the conducting of these tests, it may be revealed that not only to improve the balls outer skin would improve the desired result of increased yardage, but, it may be found that there are lighter materials that could be used that provides the height, speed, weight and distance that many golfers need to improve their sport. Through the informatio n and data provided it is anticipated that perhaps a new generation of golf ball may be a viable option for the golfing industry and provide the insight into how materials may be a potential shift in how golf balls are manufactured. A 3D model of the location of the sensors will be produced and once this data has been successfully gathered through the use of several different testing methodologies, an analysis will then detail the results.

Child Sexual Abuse Accommodation Syndrome Term Paper

Child Sexual Abuse Accommodation Syndrome - Term Paper Example In simple terms, this means that it cannot officially be diagnosed via scientific methods and thus as a result it has been the subject of much controversy between the supporters of its existence and the opposing side that demand proof of its presence (Hornor, 2010). The Child Sexual Abuse Accommodation Syndrome can be described as the way in which a child who is undergoing sexual abuse responds to the situation (Walsh & DiLillo, 2011). This includes their behavior and reaction to facing such a travesty and is considered to behind the manner in which an abused child will act in various scenarios (Kogan, 2005). The Child Sexual Abuse Accommodation Syndrome attempts to understand the thinking of a child who may be suffer through such abuse in a means to understand why they behave in the manner that they do, and it has been included in a number of court cases as a means of presenting proof that a child was abused (Kogan, 2005). Summit claimed that this syndrome consists of five stages th at a child who is being abused goes through and they include: Secrecy – This is the tendency for the child to keep what they are going through to themselves and avoid telling others especially authority figures. This can be said to as a result of a number of emotions that the child may be experiencing at that point in time that prevents them from working up the nerve to tell somebody about what is happening to them (Crosson-Tower, 2008). These emotions can include feelings like shame and embarrassment of what is going on and in many cases fear as well as the perpetrator is more likely to threaten them about disclosing what is happening to them. Helplessness – This is the second stage of CSAAS and it is where the abused child feels powerless to stop what is happening to them (Hornor, 2010). In many cases, the individual who is abusing the child is usually in a position of power, either authoritative or physical in nature which makes the child feel like they cannot do an ything to stop what is happening to them. As a result, the feeling of helplessness over the situation creeps up inside the victim (Crosson-Tower, 2008). Entrapment and accommodation – In this stage the abused child will more than likely try to deal with the situation in the best way possible and that is via accommodation of their suffering (Hornor, 2010). This may be in the form of the child making excuses for what is happening to them such as that it as a result of the fact that they have done something bad and are being punished for it (Crosson-Tower, 2008). This occurs as a result of the growth of a feeling of entrapment that rises as a bye product of the helplessness that they feel in the second stage (Walsh & DiLillo, 2011). It can be said that this is a consequence of the development of an emotional coping mechanism that helps them get through the ordeal. Delayed Disclosure – In this stage the child finally works up the courage to tell somebody what is happening to them, but this occurs after they have gone through the ordeal for a period of time (Crosson-Tower, 2008). The reason for delayed disclosure can be said to be as a result of the fact that it takes some time before a child is able to work up the nerve to tell someone about what is going as a result of the feeling of helplessness that occurs in the second stage (Hornor, 2010). It usually occurs after the child can no longer take what is going on

What does it take to build a collaborative highly effective team Essay

What does it take to build a collaborative highly effective team - Essay Example 2. The team has a lot of discussions in which everyone often participates and freely speaks their minds without any form of fear, but within the objectives of the team. All members’ ideas are heard and none of the team members fear mentioning any creative ideas they may have. It does not only take the leader to make an effective team. Likewise, the team members must also put in an effort to ensure that the team functions effectively without any problems. First, it is important as a team member to try and understand each of the other team members potential. This helps one to clearly understand what role they play in the team. Secondly, it is important to understand what role one plays in the team. Once you do, you can simply focus on your own job as part of the team. Third, after understanding your role in the team, it is easier to identify whether there is any need of improving your skills in order for one to perform better in the team. Lastly, trust among all the team members is crucial. This implies that helping each other out would be highly beneficial to the effectiveness of the team. In case one of the team members is falling behind, other members should be willing to help. The leader plays an important role on how the team operates, and it is therefore important to open up to the team members in order to make them feel like they can trust you and freely speak their mind within the group (Woodcock, 102). Secondly, it is important to realize that what works for one person may not necessarily apply to someone else. Allow the tea members to express themselves in the way they most feel comfortable. Lastly, come up with team building strategies in order to improve communication within the team and build trust among team members. The leader in the team sets the example for the other team members and it is most likely to be expected that the team members will likely mimic what the team leader does. It is important to come up with the

Collaboration and Innovation at Proctor and Gamble Case Study

Collaboration and Innovation at Proctor and Gamble - Case Study Example One of the collaborative tools that the company uses is information systems and software. Web 2.0 has been an effective social networking and collaborative tool. The firm also used unified communications, Microsoft Live Server Functionality, web conferencing with live meetings, content management and SharePoint. Two additional collaborative tools were instant messaging and Microsoft Outlook. The benefits of these tools include the ability of the workers to communicate better. The size of the company has influenced the collaborative capabilities of the company. Tools such as emails which typically work effectively to collaborate are not that effective at P&G because the company is so large and has so many employees. The employees at P&G consider newer collaborative tools more work on top of emails. In the past researchers used to write up their experiments using Microsoft Office applications, then they would print them out and glue them together page by page into notebooks. The company today uses a customized version of Microsoft tools that allows instant communication between employees. The company also created virtual databases that allowed researchers the ability to communicate with each other in a more efficient manner. Information could now be shared among the researchers. Telepresence has been very effective at Procter & Gamble due to the fact that the company has a global operation. These tools allow researchers, marketers, and managers to keep the lines of communication open. A tool that the company should use to improve its communication is Skype. Skype allows employees to achieve two way video and audio. A second tool that could enhance collaboration is to create a cellular phone application that allows the employees to upload information into a server that the employees can access

What does it take to build a collaborative highly effective team Essay

What does it take to build a collaborative highly effective team - Essay Example 2. The team has a lot of discussions in which everyone often participates and freely speaks their minds without any form of fear, but within the objectives of the team. All members’ ideas are heard and none of the team members fear mentioning any creative ideas they may have. It does not only take the leader to make an effective team. Likewise, the team members must also put in an effort to ensure that the team functions effectively without any problems. First, it is important as a team member to try and understand each of the other team members potential. This helps one to clearly understand what role they play in the team. Secondly, it is important to understand what role one plays in the team. Once you do, you can simply focus on your own job as part of the team. Third, after understanding your role in the team, it is easier to identify whether there is any need of improving your skills in order for one to perform better in the team. Lastly, trust among all the team members is crucial. This implies that helping each other out would be highly beneficial to the effectiveness of the team. In case one of the team members is falling behind, other members should be willing to help. The leader plays an important role on how the team operates, and it is therefore important to open up to the team members in order to make them feel like they can trust you and freely speak their mind within the group (Woodcock, 102). Secondly, it is important to realize that what works for one person may not necessarily apply to someone else. Allow the tea members to express themselves in the way they most feel comfortable. Lastly, come up with team building strategies in order to improve communication within the team and build trust among team members. The leader in the team sets the example for the other team members and it is most likely to be expected that the team members will likely mimic what the team leader does. It is important to come up with the

The Political System of the United Kingdom Essay Example for Free

The Political System of the United Kingdom Essay The United Kingdom has enjoyed a relatively strong government in the entire course of its history. A major part of this could be attributed to its unique but very effective political system. There are at least five aspects that had been major contributory factors in its political stability, namely: Transparency and Accountability of Government, Consensus building on major issues, Reforms on a gradual and necessary basis, Absence of threat from coups and armed overthrow of government, and the Check and Balance of powers in its three branches. England is the land of Kings and Queens. Down the years the monarchy had played a crucial role in the political system of the nation. The reigning monarch, Queen Elizabeth II remains the constitutional and Ceremonial Head of State. She continues to exercise discretionary powers like the Royal Assent for Bills from Parliament and Royal Prerogatives like appointments of Ministers, formal consent to the declaration of war by the Prime Minister and his Cabinet, and the suggestion for the dissolution of the Parliament. The last discretionary power has never been resorted to anytime in the history of the United Kingdom. The Armed Forces swear allegiance to the Queen and that makes her their Commander-in-Chief. This is also the reason why a military-backed revolt to overthrow the government would be extremely difficult in England. In both instances, dissolution of the Parliament and unconstitutional change of government, the Crown had always been very circumspect in averting constitutional crisis. The Prime Minister is the Head of Government in the United Kingdom. He is appointed by the Monarch from the Members of Parliament of the largest majority party in the House of Commons. The current Prime Minister is Gordon Brown from the Labour Party. Coming from the largest majority of Parliament, the Prime Minister possesses the ability to form a government and push for important legislation. The Prime Minister and other senior ministers, each in charge of a government department, make up the Cabinet and together they function as the Executive Branch or Government. The Prime Minister and his Cabinet are all from Parliament but they are accountable to it. There are three Ministers in each department. They are the Head or Secretary of State, the second in rank is the Minister of State and the third in rank is the Undersecretary of State. They report to Parliament regarding their work and a committee in the House of Commons oversees their work. The Prime Minister reports to the Parliament every Wednesday for the Prime Minister’s Question Time broadcasted live in radio and television and covered by the broadsheet press. This is a democratic process of Government Transparency and Accountability. Since the Bill of Rights of 1689, sovereignty resides in the Parliament or the legislature. Like most of the world’s democracies, the United Kingdom has a bicameral legislative body. The Parliament is composed of two chambers, the House of Commons and the House of Lords. The population is proportionally divided into constituencies who elect their Members of Parliament to the House of Commons. The largest majority in the House of Commons is commissioned by the Queen to form a government. This means that a government is not voted upon by the House of Commons but it does get to exercise its vote of confidence when the legislative agenda is laid out on the Speech from the Throne. The House of Lords, on the other hand is not an elected body. It used to be hereditary among aristocratic families. Presently, the House of Lords is composed of hereditary/aristocratic members, bishops or Lords Spirituals of the Church of England, and those who have made valuable contributions to England and whose memberships were approved by the Queen but are limited to their lifetime and can not be inherited by kin down the line. Both Houses do legislative work while the House of Lords are limited in powers such as in the reviews of, proposing amendments to, or veto of Bills, except of those bills related to Monetary and Finances. The Members of Parliament have no fixed term of office. There will be a General Election when the Prime Minister calls for it, but which should not be more than five years since the last one was held. There are three major parties such as the Labour, Conservative and the Liberal Democrat, each with dramatically opposing political stand on issues. In the British Parliament, however, they build on consensus with regards to issues on national order and security, economy, health and foreign policies. Interestingly, the House of Lords acts as a Court of Appeals that decides on cases with finality. The Law Lords, which is a part of the House of Lords, is the one which hears and tries cases for judgment. A review is being made to study the possibility of replacing it with a Supreme Court, in accordance with the Constitutional Reform Act of 2005. The Lord Chancellor is the Head of the Judiciary in England and Wales for 1,400 years. Today it has been replaced by the Department of Constitutional Affairs. This is a case when changes in the system is initiated whenever Parliament sees a need for it. Such ensures that the change is necessary and called for, instead of a measure that is in place but without substantial value and significance at all. The United Kingdom has a political system with features that are common with some of the world’s leading democracies, and yet, it is for the large part distinctly different. Where in some countries there is a separation of powers among their branches of government in the United Kingdom it is not the case. Government Ministers are Members of Parliament. The Law Lords are members of the House of Lords. The Prime Minister is from the Parliament’s largest majority party. Despite the overlapping functions, the checks and balance of powers are in place. The Monarch commissions the Prime Minister, the Prime Minister consults with the Monarch, the Prime Minister calls a General Election for Members of Parliament and the Prime Minister and his Cabinet report to Parliament regularly. The best thing about the political system of the United Kingdom is that it had stood the test of time. It had worked for more than a thousand years, it could work for another thousand. But like an evolving parliamentary democracy, it is still a work in progress. References Darlington, R. (2007). A Short Guide to the British Political System. Retrieved October 1, 2008 from http://www. rogerdarlington. co. uk/Britishpoliticalsystem. html. NRI Online Pty. Ltd. (2008, October 1). Political System in the UK. Retrieved October 1, 2008, from http://www. nriol. com/welcome2uk/politics-in-uk. asp.

Economic Impact Of Technology Interventions Streptokinase Economics Essay

Economic Impact Of Technology Interventions Streptokinase Economics Essay About 14 million patients in India suffer from heart attacks every year. Of these, 2.8 million patients can benefit from a clot buster drug which would save the patients life and provide room for further treatment such as medical stents if so required. Coronary heart disease claims over a million lives every year in India. There is a need for a safe and affordable clot buster drug. At the turn of the century, clot buster drug formulations were either imported or based on imported bulk drug and formulated domestically. They were expensive, equivalent to eighteen months (tPA) to two months (Streptokinase) of per capita income at that time. Cost matters more in India unlike in countries with universal health insurance as most Indians spend out of own pocket for health expenses. Given Indias prowess in generic drugs, the production capacity gap in an area of health emergency with severe consequences seems an anomaly. The gap stems from the fact that clot buster drugs are biotechnology dr ugs which require competencies quite different from those of the usual drugs based on chemical synthesis. CSIR-IMTECH, Chandigarh made efforts to develop a process to produce clot buster drugs. Initial efforts were unsuccessful, in part due to the complex nature of the animal sources based protein drug. Subsequent teams picked up the challenge again, chose a simpler molecule and after some misses, could develop a process for natural streptokinase and then recombinant streptokinase, both harnessed from micro-organisms. The misses were important steps providing crucial learning for the process development. Streptokinase technology was transferred to industry partners, natural Streptokinase to Cadila Pharma and recombinant Streptokinase to Shasun Pharma. Implementing the technology on the shopfloor faced difficulties. In the case of recombinant streptokinase, regulatory approvals took time to obtain. The knowing-doing gap was bridged by closing the competency gap through sustained engagement between the CSIR-IMTECH scientists and the managers and technology staff of the licensees. Persevera nce, team perseverance, allowing mistakes, dynamic learning from disciplined failure, give-and-take by both the scientists team and the industrial practitioners team, and a can-do, must-do, done mind-set were the keys to success. Leadership steering at both the Lab and the Industry with a commitment to collaborate and continual collaborating was crucial. This led the transition from the lab scale to industrial scale. The respective products were launched in 2001 and 2009. The results are quite encouraging. Prices have dropped (by 65 percent, to less than one month of per capita income), availability has increased, access to a life-saving medicine has risen, and patients have realized a worth of over Rs. 16,000 crores due to the CSIR-IMTECH/licensees Streptokinase. The economic impact, or the additional benefit that would be lost if this CSIR-IMTECH Streptokinase technology intervention had not been there, is assessed based on medical impact of Streptokinase and using per capita income to be Rs. 2180 crores. The Lab itself accomplished net earnings valued at Rs.1.8 crores and the Industry partners together realized value addition of Rs. 17 crores. Innovating for affordable healthcare is inclusive innovation. The benefits to patients eclipse the benefits to those who generated the technology intervention. This pursuit of innovation continues. CSIR-IMTECH has taken the science of clot-buster drugs to a level where improved Streptokinase (smarter streptokinase) molecules will have the advantages of the far more expensive animal cell line based tPA but will be much more affordable. Similarly, while access has expanded (about 120,000 standard doses), there remain millions of patients in need of this life-saving drug. More needs to be done. Introduction Heart attacks, strokes, respiratory and cardiac failure have a common enemy in blood clots in the bloodstream that can block blood supply to the heart muscle, any part of the brain or the lungs. The consequence of blockage is damage to the heart muscle, the brain cells, or the lung tissue which is usually irreversible and debilitating, if not fatal. Extreme consequences can arise if the treatment is not administered within a window of few hours (3-4.5 hours, Klabunde (2007), Hacke et. al. (2008)). Then, the heart or brain tissue, as the case may be, gets damaged which is mostly irreversible. Treatments range from clot-dissolving medication to surgical intervention such as angioplasty or insertion of stents and open chest bypass surgery. Clot busters, as clot dissolving drugs are called, attack the clot itself to dissolve it and restore blood supply. Angioplasty is an invasive and expensive procedure where blocked arteries are opened up using medical stents thus making more space for the blood supply to be restored. Similarly, bypass surgery is invasive and very expensive (see appendix 1). Prevention in high-risk patients (hardened and narrowed/blocked arteries) is via blood thinner drugs that reduce blood density allowing blood to flow through the reduced space. Despite preventive treatment, clots can form and occlusion in blood vessels can occur. Then, clot buster drugs are life saviours. In India, more than a million patients die due to coronary heart disease every year (appendix 1). Until the year 2001, no domestic production of clot-busters existed. The formulations were imported: among others, the lead formulations of Streptokinase Kabinase by Kabi Pharmacia, Sweden and Streptase by Hoechst Marion Roussel, Germany were priced then between Rs. 3000 to Rs. 4000 per vial (Krishnan (2000)). The dominant drug in this class of drugs, Tissue Plasminogen Asctivator (tPA) cost more than Rs. 30,000 per vial. Thus, clot buster drugs were expensive and the supply was short of requirement. In terms of per capita income at that time, this amounted to eighteen months of income for tPA and about two months of income for Streptokinase. The Streptokinase market was about 21 thousand vials of standard dose of 1.5 miu  [1]  . Lack of affordability could have restricted access. Given Indian pharmaceutical industrys prowess in generic drugs, realized through strengths in organic chemicals synthesis and process engineering, this raises the question about the obstacles. The Indian pharmaceutical industry was essentially based on chemical entities whereas clot buster drugs are based on biotechnology  [2]  which was almost non-existent in India around the turn of the century. Thus, access to affordable life-saving clot buster drugs was limited domestically. To make it affordable, it had to be produced domestically. To produce it domestically, a suitable technology had to be developed. The technology had then to be transitioned from a laboratory scale to an industrial scale. As in the case of affordable chemical drugs, the impetus of finding solutions and creating domestic capacity also came from CSIR Labs. In the case of generic chemical drugs, the core scientists came from Labs such as the NCL, Pune, IICT, Hyderabad and CDRI, Lucknow. These scientists and their industry contemporaries developed and implemented safe and cost effective technologies in a short time span. In the case of biotechnology, processes are being developed by IMTECH, Chandigarh and IICB, Kolkata among others. A program at IMTECH tapped into finding a solution to the problem of an affordable clot buster drug. The program has roots in projects dating back to 1989. The scientists examined the prevalent clot buster drug tissue Plasminogen Activator (tPA) but then chose instead an alternate less complex protein Streptokinase for development. This study examines the benefits realized from the Streptokinase project, specifically, the natural Streptokinase biotechnology drug licensed to Cadila Pharma and the recombinant Streptokinase drug technology licensed to Shasun Pharma Limited, to quantify the value creation and to assess the economic impact. The Industry The Indian pharmaceutical industry is among the top science based industries and focused on quality affordable drugs. It is estimated to be USD 21 billion or about Rs. 105,000 crores with exports accounting for about 40 percent (USD 8.7 billion) in 2009-10 (DOP (2011, 2012)). The industry is growing at over 10 percent per year. It is the sixth largest industry in India ranked by contribution to GDP (CSO (2011)). Globally, it ranks 3rd in terms of volume of production (10 percent of global share) and 14th largest in terms of value (1.5 percent of global share). A reason for the low value share is the lower cost of drugs in India 5 to 50 percent less than in developed countries. Thus, the Indian drugs and pharmaceutical industry is focused on affordable drugs. The Indian pharmaceutical industry is diverse. The number of units is quoted at over 20,000. However, the actual number of drug manufacturing licenses issued is about 5877 (GOI (2003))  [3]  . Registered factories are about 3500 (CSO (2011)), the rest being smaller unregistered units. The units are spread across India and provide depth that accounts for the 10 percent global volume share. Apart from MNCs such as Glaxo Smithkline, Pfizer, Astra Zeneca, several Indian companies Ranbaxy, Dr. Reddys, Cipla, Lupin and others have global operations. Biotechnology based drugs have taken root and are growing. Companies such as Biocon, Serum Institute of India, Panacea Biotec, and Reliance Life Sciences have adopted biotechnology. The biotechnology industry value exceeds Rs. 20,000 crores in 2011-12 (BioSpectrum-ABLE Biotech Survey 2012). Many Indian companies maintain the highest standards in purity, stability and international safety, health and environmental protection in production and supply of bulk drugs to buyer companies, who in turn are subject to stringent assessment by regulatory authorities in importing countries. These companies have secured regulatory approvals from USFDA, MHRA-UK, TGA-Australia, MCC-South Africa for their plants. Quality with certification is also a feature among many Indian pharmaceutical companies. During the last decade, the industry has embraced new technologies and adapted to regulatory regimes more aligned to international regulatory regimes. New business models have emerged to cope with and thrive in this environment. All of these have a bearing on the development of a domestic clot buster drug, namely, Streptokinase. With the advent of product patents in India from the 2005 amendment to the Patents Act, the focus has shifted from process engineering to drug discovery. Process engineering remains important. Several drugs will go off patent over the next few years and supply of cost effective quality generics would benefit the industry and the consumers. However, drug discovery is the new mantra. Drug discovery is a highly uncertain multi-million multi-year activity. For every one new drug molecule approved, the pipeline requires about twelve molecules for clinical trials candidacy. For every molecule reaching clinical candidacy, the pipeline of molecules is three molecules based on current success rates at each stage. The total costs spiral to over USD 600  [4]  million per new drug molecule in the USA over a span of a decade. Patent protection allows recovery of the investment but also makes the drug expensive. In India, the cost per new drug molecule can drop to less than USD 150 million due to lower costs (such as those of clinical trials). This lower cost is encouraging Indian drug enterprises to engage in drug discovery as they adapt to the product regime. However, even at the reduced cost in India, the drug would still be expensive and out of reach of many Indians. Drugs capacity building in India appears to be addressing reduction in costs and so also in the time span for drug discovery. Specialization along the chain of drug discovery via outsourcing is one emerging business model. Thus, RD is being shaped by Contract Research Organizations (CROs), Drug Discovery Development (DDD) and Clinical Trials Organizations (CTO). Manufacturing is by large integrated companies as also by Contract Manufacturers. Marketing is also by Contract Marketers and co-marketing alliances (IBEF (2010), KPMG (2006)). While regulatory changes may be the trigger for drug discovery, demand for drugs for Indian diseases is also an impetus. Chief among these are drugs for infective diseases found in India but not much in developed countries such as tuberculosis, malaria, typhoid, cholera etc. These diseases are far more prevalent in developing countries such as India where affordability is a key issue. Profits from patented multi-billion drug molecules will be tough to realize for these diseases. Thus, effective new molecules for these diseases would have to be developed within India. A major initiative underway in this regard is the Open Source Drug Discovery (OSDD) project of CSIR which seeks to harness talent across boundaries, cutting costs and hopes to reduce drug discovery time. It is open source and thus drug molecules found will be distributed without the higher price due to profits associated with patents. Costs will be cut down to the collaborative nature of the initiative. Incentives to col laborators are based on contributing to drug discovery for debilitating diseases and the recognition among peers. Also important are drugs for the so called lifestyle diseases such as diabetes (about 50 million diabetics in India as per Ramachandran et. al. (2010)) and hypertension (65 million hypertension patients in India as per Gupta (2004)), both high risk factors for emergencies such as heart attacks, strokes and respiratory failure. India is estimated to have about 14 million patients that suffer from myocardial infarction or heart attacks every year, of which 80 percent patients may not be receiving proper medical care (Financial Express (2002)). About 20 percent (2.8 million) of the cardiac patients population in India could use a clot buster drug. Only a fraction (about 200, 000 or under 10 percent) of these patients undergo bypass surgeries or angioplasty. The rest of the patients (2.6 million) could be treated with clot buster drugs administered within a window of 3-4.5 hours to the patient. Recall that there are over a million deaths every year due to coronary heart disease in India. With a growing number of diabetes and hypertension patients in India, and so increasing chances of blood vessel occlusion related deaths, having access to an affordable clot buster drug is going to be increasingly more important. An added advantage is the possibility of exports of these drugs since the diseases addressed are prevalent globally. The Technology Gap, Development and Commercialization A domestic clot buster drug was missing, as discussed earlier. The choice among three prevalent drugs narrowed to Streptokinase. Streptokinase is a 47kD  [5]  protein composed of 414 amino acids produced by several strains of beta hemolytic streptococci. It dissolves a clot occluding blood supply through a 3-step process. First, Streptokinase forms a complex with plasminogen (Pg). This 1:1 complex (the Partner Pg) rapidly becomes proteolytically active. Second, the Partner Pg complex acts on substrate Pg molecules in circulation to convert them to plasmin (Pn), the active form of the pro-enzyme Pg. Plasmin is a protease that is capable of breaking apart cross-links between fibrin molecules, which provide the structural integrity of blood clots. So, third, the plasmin rapidly dissolves the pathological clot occluding blood supply to the heart muscle in case of myocardial infarction, to brain tissue in case of stroke or to the lungs in case of respiratory failure. The Lab, Research Capacity and Technology Development Technology development has been enabled by science research and ongoing (and predecessor) projects at CSIR-IMTECH. The focus is science and technology related to microbial products. A key area is recombinant gene technology based products. One initiative relates to developing a domestic clot buster drug. The initial attempt in late 1980s focused on the prevalent drug tissue Plasminogen Activator (tPA) which is naturally found in the human body in small quantities. Through recombinant gene technology, a pioneer of the field, Professor Collen and his organization Genentech USA produced tPA from animal cell lines in the early 1980s. Attempts to replicate tPA production in IMTECH did not fructify partly due to the volatile external environment prevalent at that time and so the lack of enough scientists to execute the task. During the early 1990s, subsequently, another team of scientists at IMTECH chose an alternative to tPA, namely, Streptokinase for development due to its simpler structure and higher probability of success in developing a novel process for domestic production. The process involved two key competencies protein science and cloning science among others. Technical problems arose again in implementing the recombinant gene technology. The scientists decided to down-shift to developing a process for producing Streptokinase from natural sources. It involves two main processes fermentation (protein production) and purification (separating the protein from the broth, purified to an extent that it is admissible to humans). This effort was successful lending both credibility to the process and boosting the morale of the scientists concerned. The first success helped to delineate the tasks possible from the tasks not possible (appendix 2). This paved the way for producing Streptokinase using re combinant gene technology increasing yield many times over. The key process innovation was the use of 2-step chromatography for purification. Leadership Throughout the years of development spanning 1989 onward, the scientists at CSIR-IMTECH were supported by the science leadership and management comprising four different institute directors and two different director-generals  [6]  . Leadership and institutional continuity combined with scientific ingenuity and perseverance to produce first natural and then recombinant streptokinase. The agenda continues and smart Streptokinase is under development which could be a life-saving and life-enhancing product not only for India and the developing nations but also for the developed countries. The Technology Transfer, Technology Embedding and Commercialization The lab scale success has to be transitioned to industrial scale and commercial success. Subsequent to the transfer of know-how on fermentation and purification processes and the strain, implementation at an industrial scale also faced many hurdles. While the science was established at the Lab with lab scale production, the transition to industrial scale volumes threw up challenges (see appendix 2). As at the Lab level, informed hit and trial, learning from failure, delineating what not to do from what to do helped to transition the technology to industrial scale. Standardization of the industrial biotechnology process entailed initial training, repeated training and embedding the technology in the licensees premises. IMTECH engaged with the licensees and remained engaged thereby providing a lot of handholding in the journey from the lab to factory production. This case is an example of disciplined failure where learning from initial failure led to a course change, technological succ ess, commercial success, and then again picking up the more difficult task and taking it to fruition. CSIR-IMTECH first developed a technology to produce natural Streptokinase from Streptococci. It was developed in 4 years by 1998-99, licensed and transferred in 1999-2000 and launched commercially in 2001-2002. The recombinant Streptokinase was developed in 5 years by the year 2001-2002, licensed and transferred in 2002-2003 and commercially launched in 2009-10. Natural Streptokinase know-how was licensed to Cadila Limited for fees of Rs. 20 lakhs and royalty based on ex-factory sales for 5 years. This drug was launched as STPASE injection in year 2001-02. Subsequently, recombinant gene technology was licensed by CSIR-IMTECH to Shasun Pharmaceuticals Limited, Chennai for a fee of Rs. 1 crore and royalty payments based on ex-factory sales for 5 years. The drug was launched in July 2009 and marketed by Lupin Pharma as LUPIFLO. Comparison with prevalent alternate treatments Prior to adoption of Streptokinase for clot-blockade led heart attacks, the treatments were generalized and included oxygenation and intensive care (appendix 1). Subsequent to studies of randomized controlled trials establishing efficacy and superiority of Streptokinase, it was adopted widely specially in Europe. Later, other clot busting drugs were developed. Still later, open heart bypass surgery and then angioplasty using medical stents were developed. Clot buster drugs are more affordable than surgical treatments. Within the class of clot buster drugs, Streptokinase remains the most affordable. Its costs are lower since its production is micro-organism based unlike the others derived from animal cell lines. Comparison with prevalent competing technologies clot-busters Clot-buster drugs in use are tissue plasminogen activator (tPA), Streptokinase, and Urokinase. Streptokinase competes with tissue plasminogen activator (tPA) which is the prevalent clot buster drug. tPA is preferred for its target (blood clot causing blockade) specificity. The advantage of tPA over Streptokinase is in the extent of systemic fibrinogenolysis generated by each. The resultant side effect of bleeding (due to suppression of clot formation by plasmin) can be higher for Streptokinase. However, studies have established that streptokinase is as effective in saving lives in mycocardial infarction as is tPA, despite the nearly ten-fold higher price of the latter. tPA is expensive enough to be inaccessible to most patients for this life threatening condition. Recombinant tPA reduced prices but the cost remains many times over that of Streptokinase. Cost of treatment is of utmost importance as most Indians health expenditure is out of own pocket. Appendix 1 clearly indicates that while the treatments for myocardial infarction vary from Streptokinase to tPA to angioplasty and bypass surgery, for a vast majority of Indians (with annual income about and below the current per capita annual income of Rs. 60,000), the treatment affordable and so possible is administering of Streptokinase. The alternative to Streptokinase would be a mix of morphine, oxygenation, intensive-care. Comparison with prevalent manufacturers Producers of natural Streptokinase, for several years, were only MNCs such as Behring-werke (Germany) and Lederle (USA). In India, before CSIR-IMTECHs intervention, Streptokinase was imported, Streptokinase injections were sold by MNCs Kabinase by Kabi Pharmacia, Sweden and Streptase by Hoechst Marion Roussel, Germany and priced then between Rs. 3000 to Rs. 4000 per vial in year 2000 (Krishnan(2000)). tPA prices varied from Rs. 30,000 per vial in year 2000-01 to about Rs. 19,000 per vial in 2010-11. In India, CSIR-IMTECH licensee Cadila Pharmaceuticals Ltd. manufactured Streptokinase as STPASE at an ex-factory price of Rs. 900 per vial (standard 1.5 miu dose) in 2001-02. The recombinant Streptokinase which has the same biological properties of natural Streptokinase (but much higher yields) was produced by CSIR-IMTECH licensee Shasun Chemicals and Drugs Limited, Chennai at an ex-factory price of Rs. 465 per vial in year 2009-10. This is the bulk drug price. It is marketed as LUPIFLO by Lupin Pharmaceuticals Limited and as STUKINASE by Samarth Pharma among other formulators. Non-CSIR licensee entry also occurred after the first CSIR licensee entered. There were three entrants, two of whom have already exited. The third entrant, Biocon, is successfully producing recombinant Streptokinase and marketing it as Myokinase. Data and Methodology Lab data are obtained from CSIR-IMTECH. Industry data are obtained through questionnaires and interviews. Market data such as sales value and quantity numbers for Streptokinase formulations/brands along with data on company characteristics such as MNC/Indian, date of launch, size of formulation are from the IMS Health India database on Streptokinase. The data are collected at the stockist level and are representative of the Indian pharmaceuticals market with the exception of sales directly from producers/formulators to the hospitals. Given the retrospective nature of this economic impact study, and the difficulties in collecting past data, the initial methodology proposed was a contemporaneous difference analysis between CSIR licensees and comparable enterprises. However, Streptokinase producer data could not be collected despite mailed questionnaires followed up with interviews  [7]  . Instead, for the industry analysis, market sales and volume data for a panel of 20 years are used to estimate a demand function with pooled OLS regressions. The pooled regressions permit segregation of estimates for CSIR licensees from others, and, of estimates over time  [8]  . Benefits of the Technology Intervention Creating Value Benefits to the Lab CSIR-IMTECH developed a technology and plugged a production capacity gap for a life-saving drug. The first of the series of streptokinase molecules established the credibility of CSIR as a solutions provider based on their science rooted program for technology. IMTECH scientists successfully integrated science and application producing more improved molecules and earned fees and royalty in the process. The total value of fees and royalty received is about Rs. 2.5 crores and the investment in terms of salaries and cost of patents is about Rs. 65 lakhs in 2011-12 prices. The internal rate of return on the Labs cash flows for Streptokinase works out to 36 percent  [9]  . Thus, the technology program is quite cost effective for CSIR. Benefits to CSIR Licensees and the Industry The direct benefit to the licensees in terms of value addition thus far (from 2001-02 to 2011-12) is about Rs. 17 crores in 2011-12 prices, the bulk of it, Rs. 16.5 crores, arising from the first licensee Cadila Pharma Limited. The second CSIR licensee Shasun Limited has limited value added from its two years of Streptokinase operations. The first molecule served as a proof-of-concept for the industry and even more as a proof-of-value creation. It was followed by another successful molecule variant and commercial success with that also. From no producer of Streptokinase in year 2000, there are now at least three producers domestically. The third producer Biocon, a non-CSIR licensee, is among three entrants, the other two having exited already. In 2001, before entry of the first domestic producer, CSIR-IMTECH licensee Cadila Pharma, there were about four Streptokinase brands and sales value was about Rs. 6 crores with about 20 thousand vials of standard dose. The value of the Streptokinase industry is over Rs. 20  [10]  crores in 2011 with about 118 thousand vials in terms of the standard dose of 1.5 miu and about thirty brands (including different vial sizes) marketed. While many factors are responsible for this value increase, demonstration of the proof- of-concept (technology works) and the proof-of-value (commercial success) by CSIR-IMTECH scientists and licensees may have been crucial. Without these, the country may still have been importing the drug at much higher prices. To that extent, the country is also saving foreign exchange. The current market price of STPASE is reported to be about Rs. 1000 per vial and the prices of Streptokinase vials from Shasuns bulk drug vary from Rs.715 to Rs. 2300. Myokinase, the third non-CSIR entrant Biocons product, is reportedly selling at a price of about Rs. 2000 per vial. The average market price is about Rs. 1700 per vial (standard 1.5 miu dose). Prices of streptokinase by CSIR-IMTECH licensees are among the lowest in the industry, where over 30 versions of formulations are now being marketed domestically. Industry Competition With increasing market competition, prices drop and sales increase. Competition can be enhanced more by entry of producers. A pioneering paper (Bresnahan and Reiss 1991) developed an empirical framework for measuring the effects of entry in concentrated markets by studying the relationship between the number of firms in the market, market size, and competition. Their analysis suggests that competitive conduct changes quickly as the number of incumbents increases. In markets with five or fewer incumbents, almost all variation in competitive conduct occurs with the entry of the second or third firm. Surprisingly, once the market has between three and five firms, the next entrant has little effect on competitive conduct. In the absence of data on price-cost margins, they develop another key metric the ratio of break-even sales Sn+1/Sn where n refers to the last incumbent producer and n+1 refers to the entrant. This threshold is equal to one in perfectly competitive markets where the minimum efficient scale of production is quite low relative to the market size and there are no entry barriers. In concentrated markets, the threshold of break-even sales ratio is higher than one due to substantial fixed costs as well as entry barriers. A new entrant could incur higher fixed capital cost and/or higher variable costs (such as marketing costs to establish their product and realize sales). With increasing entry, this threshold break-even sales ratio should decline and approach the value of one as in perfect competition. While we do not observe price-cost margins for all three domestic producers of Streptokinase Cadila (entry in year 2001), Biocon (entry in 2008) and Shasun (entry in 2009) we do have information on sales  [11]  and company provided break-even years. Using the Bresnahan and Reiss (1991) framework, the calculation of break-even sales (quantity of vials) ratio is found to be 2.8 for the second entrant (Biocon, relative to first producer Cadila Pharma) and 1.6 for the third entrant (Shasun Pharma, relative to Biocon)  [12]  . This quick examination points to a decreasing value of the break-even sales ratio and fast increasing competition with just three entrants, much in line with the findings of the Bresnahan and Reiss paper. Benefits to the People and the Economy Price Reduction, Affordability and Access

Pathophysiology Repeort on Eosinophilic Esophagitis Essay -- Disease,

A relatively new diagnosis in the medical field is Eosinophilc Esophagitis. This disease has emerged all around the world and became a more common diagnosis beginning in the 2000’s. According to doctors at the Cincinnati Children’s Hospital Medical Center, 1-4 in 10,000 people live with this disease (Cincinnati, 2012, p. 1). Food allergies often accompany this disease, which may be why it is becoming better known. The pathophysiology behind Eosinophilic Esophagitis is extensive, and includes the parts of the body that are effected, normal function, symptoms and cause of symptoms, diagnosis, physiology, and treatment. Eosinophilic Esophagitis is a disease that affects the esophagus. Other parts of the gastrointestinal tract can also be affected but if that is the case, the disease is renamed according to the area affected. Eosinophilic Esophagitis (EE) causes the esophagus to be narrower than usual, known as esophageal stricture. This is due to the presence of eosinophils. Eosinophils are white blood cells, produced in bone marrow, that are most commonly found in the gastrointestinal tract. They normally function by killing off microorganisms, such as parasites. In EE, certain stimuli can cause increased production and buildup of excess eosinophils. Since the esophagus narrows due to this disease, dysphagia and food impaction commonly occur. Eosinophils can also cause thinning of the esophageal lining. This makes the lining more susceptible to being punctured by contents traveling down the esophagus. The esophagus is also affected by the disease because it is linked to acid reflex. Reflux can cause break down and damage to the esophageal lining. Finally, Peristalsis or the involuntary movement of food through the esop... ...4) Eosinophilic esophagitis. The New England Journal of Medicinc. Retrieved From http://www.nejm.org/doi/full/10.1056/NEJM200408263510924#t=article Nurko, S., & Furuta, T. G. (2006). Eosinophilic esophagitis. Retrieved From http://www.nature.com/gimo/contents/pt1/full/gimo49.html The American Partnership for Eosinophilic Disorders (2008). Eosinophilic associated gastrointestinal disorders: About EGID. Richmond, Texas: The American Partnership for Eosinophilic Disorders. [Brochure] The American Partnership for Eosinophilic Disorders (2008). Eosinophilic esophagitis: About EE. Richmond, Texas: The American Partnership for Eosinophilic Disorders. [Brochure] The International Gastrointestinal Eosinophil Researchers. A guide to eosinophilic esophagitis in children and adults. Flourtown, PA: Children’s Digestive Health & Nutrition Foundation. [Brochure]